Please use this identifier to cite or link to this item: https://hdl.handle.net/10620/4499
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dc.contributor.authorSung, Ven
dc.contributor.authorLiu, Ren
dc.contributor.authorWake, Men
dc.contributor.authorOlds, Ten
dc.contributor.authorZubrick, Sen
dc.contributor.authorWang, Jen
dc.contributor.authorGrobler, Aen
dc.contributor.authorCarew, Pen
dc.contributor.authorLycett, Ken
dc.date.accessioned2019-06-14T23:53:26Zen
dc.date.accessioned2019-05-23T01:58:31Zen
dc.date.available2019-06-14T23:53:26Zen
dc.date.available2019-05-23T01:58:31Zen
dc.date.issued2018-10en
dc.identifier.urihttps://hdl.handle.net/10620/18395en
dc.identifier.urihttp://hdl.handle.net/10620/4499en
dc.description.abstractBackground Hearing loss is a disabling condition whose prevalence rises with age. Obesity—a risk factor common to many non-communicable diseases—now appears to be implicated. We aimed to determine: (1) cross-sectional associations of body composition measures with hearing in mid-childhood and mid-life and (2) its longitudinal associations with 10-year body mass index (BMI) trajectories. Methods Design & Participants: There were 1481 11–12-year-old children and 1266 mothers in the population-based cross-sectional CheckPoint study nested within the Longitudinal Study of Australian Children (LSAC). Anthropometry (CheckPoint): BMI, fat/fat-free mass indices, waist-to-height ratio; LSAC wave 2–6-biennial measured BMI. Audiometry (CheckPoint): Mean hearing threshold across 1, 2 and 4 kHz; hearing loss (threshold > 15 dB HL, better ear). Analysis: Latent class models identifying BMI trajectories; linear/logistic regression quantifying associations of body composition/trajectories with hearing threshold/loss. Results Measures of adiposity, but not fat-free mass, were cross-sectionally associated with hearing. Fat mass index predicted the hearing threshold and loss in children (β 0.6, 95% confidence interval (CI) 0.3–0.8, P < 0.001;, odds ratio (OR) 1.2, 95% CI 1.0–1.4, P = 0.05) and mothers (β 0.8, 95% CI 0.5–1.2, P < 0.001; OR 1.2, 95% CI 1.1–1.4, P = 0.003). Concurrent obesity (OR 1.5, 95% CI 1.1–2.1, P = 0.02) and waist-to-height ratio (WHtR) ≥ 0.6 (OR 1.6, 95% CI 1.2–2.3, P = 0.01) predicted maternal hearing, with similar but attenuated patterns in children. In longitudinal analyses, mothers’, but not children’s, BMI trajectories predicted hearing (OR for severely obese 3.0, 95% CI 1.4–6.6, P = 0.01). Conclusions Concurrent adiposity and decade-long BMI trajectories showed small, but clear, associations with poor hearing in mid-life women, with emergent patterns by mid-childhood. This suggests that obesity may play a role in the rising global burden of hearing loss. Replication and mechanistic and body compositional studies could elucidate possible causal relationships.en
dc.subjectHealthen
dc.titleHow body composition influences hearing status by mid-childhood and mid-life: The Longitudinal Study of Australian Children.en
dc.typeJournal Articlesen
dc.identifier.urlhttps://www.nature.com/articles/s41366-018-0170-6en
dc.identifier.surveyLSACen
dc.identifier.journalInternational Journal of Obesityen
dc.identifier.volume42en
dc.description.pages10en
dc.identifier.issue10en
local.identifier.id5092en
dc.publisher.cityParkvilleen
dc.subject.dssHealth and wellbeingen
dc.relation.surveyLSACen
dc.old.surveyvalueLSACen
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Articles-
item.fulltextNo Fulltext-
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